作者
Adam D DeVore, Steven McNulty, Fawaz Alenezi, Mads Ersboll, Justin M Vader, Jae K Oh, Grace Lin, Margaret M Redfield, Gregory Lewis, Marc J Semigran, Kevin J Anstrom, Adrian F Hernandez, Eric J Velazquez
发表日期
2017/7
期刊
European journal of heart failure
卷号
19
期号
7
页码范围
893-900
出版商
John Wiley & Sons, Ltd
简介
Background
While abnormal left ventricular (LV) global longitudinal strain (GLS) has been described in patients with heart failure with preserved ejection fraction (HFpEF), its prevalence and clinical significance are poorly understood.
Methods and results
Patients enrolled in the RELAX trial of sildenafil in HFpEF (LV ejection fraction ≥50%) in whom two‐dimensional, speckle‐tracking LV GLS was possible (n = 187) were analysed. The distribution of LV GLS and its associations with clinical characteristics, LV structure and function, biomarkers, exercise capacity and quality of life were assessed. Baseline median LV GLS was −14.6% (25th and 75th percentile, −17.0% and −11.9%, respectively) and abnormal (≥ − 16%) in 122/187 (65%) patients. Patients in the tertile with the best LV GLS had lower N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) [median 505 pg/mL (161, 1065) vs. 875 pg/mL (488 …
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