作者
Oliver Kepp, Laura Senovilla, Ilio Vitale, Erika Vacchelli, Sandy Adjemian, Patrizia Agostinis, Lionel Apetoh, Fernando Aranda, Vincenzo Barnaba, Norma Bloy, Laura Bracci, Karine Breckpot, David Brough, Aitziber Buqué, Maria G Castro, Mara Cirone, Maria I Colombo, Isabelle Cremer, Sandra Demaria, Luciana Dini, Aristides G Eliopoulos, Alberto Faggioni, Silvia C Formenti, Jitka Fučíková, Lucia Gabriele, Udo S Gaipl, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Nathalia A Giese, Zong Sheng Guo, Akseli Hemminki, Martin Herrmann, James W Hodge, Stefan Holdenrieder, Jamie Honeychurch, Hong-Min Hu, Xing Huang, Tim M Illidge, Koji Kono, Mladen Korbelik, Dmitri V Krysko, Sherene Loi, Pedro R Lowenstein, Enrico Lugli, Yuting Ma, Frank Madeo, Angelo A Manfredi, Isabelle Martins, Domenico Mavilio, Laurie Menger, Nicolò Merendino, Michael Michaud, Gregoire Mignot, Karen L Mossman, Gabriele Multhoff, Rudolf Oehler, Fabio Palombo, Theocharis Panaretakis, Jonathan Pol, Enrico Proietti, Jean-Ehrland Ricci, Chiara Riganti, Patrizia Rovere-Querini, Anna Rubartelli, Antonella Sistigu, Mark J Smyth, Juergen Sonnemann, Radek Spisek, John Stagg, Abdul Qader Sukkurwala, Eric Tartour, Andrew Thorburn, Stephen H Thorne, Peter Vandenabeele, Francesca Velotti, Samuel T Workenhe, Haining Yang, Wei-Xing Zong, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi
发表日期
2014/9/2
来源
Oncoimmunology
卷号
3
期号
9
页码范围
e955691
出版商
Taylor & Francis
简介
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named “immunogenic cell death” (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defects in the components that underlie the capacity of the immune system to perceive cell death as immunogenic negatively influence disease outcome among cancer patients treated with ICD inducers. Thus, ICD has …
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O Kepp, L Senovilla, I Vitale, E Vacchelli, S Adjemian… - Oncoimmunology, 2014