查看文章

We have previously reported that, depending on their activation status, mouse γδ T cells can either enhance or inhibit the activity of IL-17+ autoreactive T cells in experimental autoimmune uveitis. In this study, we showed that γδ T cells in naive C57BL/6 (B6) mouse do not express the IL-23R, whereas in immunized mice, it is expressed on> 50% of γδ T cells. In vitro studies showed that IL-23R expression on γδ T cells is modulated by their state of activation, as weakly activated γδ T cells expressed the IL-23R, but highly activated γδ T cells did not. Functional studies showed that IL-23R+ γδ T cells had the strongest suppressive effect on IL-17+ autoreactive T cells, and that this effect was inhibited when the IL-23R was blocked by anti–IL-23R Ab or in the presence of excessive amounts of exogenous IL-23. We conclude that the balance between the enhancing and inhibitory effects of γδ T cells is regulated by their …