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This paper presents a 3D numerical simulation on a microfluidic device for creating double emulsions, controlling their sizes, and also manipulating the encapsulation process using a two-sequential co-flowing microfluidic configuration. In the proposed geometry, double emulsions can be generated as a result of the liquid’s interaction using dripping instability in a highly controllable manner. Dimensionless numbers, including Weber and capillary of the inner phase (We_in and Ca_in), Weber and capillary of the middle phase (We_mid and Ca_mid), and capillary number of the outer phase (Ca_out) are considered to peruse effects of the phase flow rates on compound droplets characteristics. The mentioned dimensionless parameters can individually affect the formation process of the compound droplet, size of the inner and the outer droplets, and formation frequency. A three-dimensional numerical model based on the …