作者
Amirmohammad Sattari, Sajjad Janfaza, Mohsen Mashhadi Keshtiban, Nishat Tasnim, Pedram Hanafizadeh, Mina Hoorfar
发表日期
2021
期刊
ACS Omega
卷号
6
期号
40
页码范围
25964-25971
出版商
ACS publications
简介
Microfluidic on-chip production of microgels employing external gelation has numerous biological and pharmaceutical applications, particularly for the encapsulation of delicate cargos; however, the on-chip production of microgels in microfluidic devices can be challenging due to problems such as clogging caused by accelerated progress in precursor solution viscosity. Here, we introduce a novel microfluidic design incorporating two consecutive coflow geometries for microfluidic droplet generation. A shielding oil phase is employed to avoid emulsification and gelation stages from occurring simultaneously, thereby preventing clogging. The results revealed that the microfluidic device could generate highly monodispersed spherical droplets (coefficient of variation < 3%) with an average diameter in the range of 60–200 μm. Additionally, it was demonstrated that the device could appropriately create a shelter of the oil …
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