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Objectives.  Personality factors parsimoniously capture the variation in dispositional characteristics that affect behaviours, but their value in predicting medication non‐adherence is unclear. We investigated the relationship between five‐factor model personality factors (Conscientiousness, Neuroticism, Agreeableness, Extraversion, and Openness) and medication non‐adherence among older participants during a six‐year randomized placebo‐controlled trial (RCT).

Design.  Observational cohort data from 771 subjects aged ≥72 years enrolled in the Ginkgo Evaluation of Memory study, a RCT of Ginkgo biloba for prevention of dementia.

Methods.  Random effects logistic regression analyses examined effects of NEO Five‐Factor Inventory scores on medication non‐adherence, determined via pill counts every 6 months (median follow‐up 6.1 years) and defined as taking <80% of prescribed pills. Analyses …