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The 100th meridian bisects the Great Plains of the United States and effectively divides the continent into more arid western and less arid eastern halves and is well expressed in terms of vegetation, land hydrology, crops, and the farm economy. Here, it is considered how this arid–humid divide will change in intensity and location during the current century under rising greenhouse gases. It is first shown that state-of-the-art climate models from phase 5 of the Coupled Model Intercomparison Project generally underestimate the degree of aridity of the United States and simulate an arid–humid divide that is too diffuse. These biases are traced to excessive precipitation and evapotranspiration and inadequate blocking of eastward moisture flux by the Pacific coastal ranges and Rockies. Bias-corrected future projections are developed that modify observationally based measures of aridity by the model-projected …