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Introduction: Free radicals play an effective role in the pathogenesis of different pathological diseases together with cancer which is the second leading cause of cancer death in women worldwide and the main aim of this study was to estimate the of Thrombospondin (TSP-1), TAS, malondialdehyde (MDA), Paraoxonase (PON-1), and arylesterase (ARE), selenium (SE), and G6PD as antioxidant capability in breast cancer patients and to compare with apparently healthy individuals. Methods: A total of 150 subjects were recruited which included 75 patients (age range 25 to 45 years) with BC attending the Kirkuk Teaching Hospital (Kirkuk province), were enrolled in this study, in a period from 15 December 2019 to 20 March 2020. and 75 controls (age and sex matched). The analysis of covariance was used to identify any significant differences and statistical significance was set at P< 0.05.

Results: The activity of TSP-1, PON-1, ARE, SE, and TAS were significantly lower in patients compared to control group. The level of MDA, and G6PD were significantly higher in patients versus the healthy group. Conclusion: Breast cancer patients demonstrate raised oxidative stress compared to healthy subjects.