作者
Sadahisa Okuhara, Takeji Umemura, Satoru Joshita, Soichiro Shibata, Takefumi Kimura, Susumu Morita, Michiharu Komatsu, Akihiro Matsumoto, Kaname Yoshizawa, Yoshihiko Katsuyama, Masao Ota, Eiji Tanaka
发表日期
2014/10
期刊
Hepatology Research
卷号
44
期号
10
页码范围
E172-E180
简介
Aim
We sought to clarify the associations between serum cytokines and chemokines, hepatitis B surface antigen (HBsAg), hepatitis B core‐related antigen (HBcrAg), and hepatitis B virus (HBV) DNA and response to entecavir therapy in chronic hepatitis B.
Methods
We analyzed six cytokines (interleukin [IL]‐2, IL‐6, IL‐10, IL‐12p70, IL‐21 and IL‐22) and five chemokines (CCL2, CCL3, CXCL9, CXCL10 and CXCL11) before and at 6, 12 and 24 months during entecavir therapy in 48 chronic hepatitis B patients. Quantitative measurement of HBsAg, HBcrAg and HBV DNA was performed. A virological response (VR) was defined as serum HBV DNA of less than 2.1 log copies/mL by treatment month 24.
Results
Thirty‐nine patients (81%) achieved a VR. Serum IL‐6 (P = 0.031), CXCL‐9 (P = 0.002), and CXCL‐10 (P = 0.001) were high in chronic HBV and correlated positively with transaminases and bilirubin …
学术搜索中的文章
S Okuhara, T Umemura, S Joshita, S Shibata, T Kimura… - Hepatology Research, 2014