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Background and Objective: When nanoparticles interact with blood components in the blood circulation, they can potentially affect the function of normal blood cells, leading to anemia, infection and bleeding or thrombosis. The aim of this study was to investigate the toxicity and the hematological alternations induced by intraperitoneal (IP) injection of two forms of gold and iron nanoparticles in a mouse model. Materials and Methods: A total of twenty male healthy adult BALB/c mice weighing about 25-30 g were divided into four groups for the study. The control group received the vehicle, while the other three groups were injected intraperitoneally with 10 mg kgG1 b.wt., of polyethylene glycol (PEG) Gold particles AuNPs, Au-Dye NPs and dextran coated cross-linked iron oxide (CLIO) NPs, consequently. Hematological parameters were measured utilizing standard CBC techniques. Results: The PEGylated (PEG) gold …