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Objective:

The objective of this study was to update the mortality experience of a cohort of workers with and without potential exposure to acrylamide (AMD) at three US plants (n= 8508) and one plant in The Netherlands (n= 344).

Methods:

We computed standardized mortality ratios (SMRs) using national and local rates and modeled internal cohort rates to assess site-specific cancer risks by demographic and work history factors and several exposure indicators for AMD.

Results:

For the 1925–2002 study period, we observed both deficit and excess overall mortality risks among the US cohort for cancer sites implicated in experimental animal studies: brain and other central nervous system (SMR= 0.67, confidence interval [CI]= 0.40–1.05), thyroid gland (SMR= 1.38, CI= 0.28–4.02), testis and other male genital organs (SMR= 0.64, CI= 0.08–2.30); and for sites selected in earlier exploratory analyses of this cohort …