作者
Philippe De Wals, Ira David Rusen, Nora S Lee, Pascale Morin, Théophile Niyonsenga
发表日期
2003/11
期刊
Birth Defects Research Part A: Clinical and Molecular Teratology
卷号
67
期号
11
页码范围
919-923
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
In Canada, the first recommendations on the use of folic acid (FA) supplements by women planning a pregnancy or capable of becoming pregnant were issued in 1993. In 1998, fortification of flour with FA became mandatory. The objective of this study was to assess the impact of these measures on the prevalence of neural tube defects (NTDs) in the province of Quebec.
METHODS
The study population included stillbirths, live births, and elective terminations for fetal malformations that were reported in 1992–2000 for women residing in the province of Quebec. NTD cases were identified from stillbirth certificates and hospital discharge summaries.
RESULTS
There was a marked decrease in the total NTD rate after 1997. The average NTD rate was 1.89 per 1000 total births during the period of 1992–1997, and 1.28 per 1000 in 1998–2000, a 32% reduction (p < 0.001).
CONCLUSIONS …
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P De Wals, ID Rusen, NS Lee, P Morin, T Niyonsenga - Birth Defects Research Part A: Clinical and Molecular …, 2003