作者
Emily B Wong, Marielle C Gold, Erin W Meermeier, Bongiwe Z Xulu, Sharon Khuzwayo, Zuri A Sullivan, Eisa Mahyari, Zoe Rogers, Hénrik Kløverpris, Prabhat K Sharma, Aneta H Worley, Umesh Lalloo, Prinita Baijnath, Anish Ambaram, Leon Naidoo, Moosa Suleman, Rajhmun Madansein, James E McLaren, Kristin Ladell, Kelly L Miners, David A Price, Samuel M Behar, Morten Nielsen, Victoria O Kasprowicz, Alasdair Leslie, William R Bishai, Thumbi Ndung’u, David M Lewinsohn
发表日期
2019/6/5
期刊
Communications biology
卷号
2
期号
1
页码范围
203
出版商
Nature Publishing Group UK
简介
Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2+ semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of bacterial and mycobacterial infections in murine models. Here, we report that a population of pro-inflammatory TRAV1-2+ CD8+ T cells are present in the airways and lungs of healthy individuals and are enriched in bronchoalveolar fluid of patients with active pulmonary tuberculosis (TB). High-throughput T cell receptor analysis reveals oligoclonal expansions of canonical and donor-unique TRAV1-2+ MAIT-consistent TCRα sequences within this population. Some of these cells demonstrate MR1-restricted mycobacterial reactivity and phenotypes suggestive of MAIT cell identity. These findings demonstrate enrichment of TRAV1-2+ CD8+ T cells with MAIT or MAIT-like …
学术搜索中的文章
EB Wong, MC Gold, EW Meermeier, BZ Xulu… - Communications biology, 2019