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A biocompatible nanodrug delivery formulation based on poly (D, L-lactide-co-glycolic) acid (PLGA), polyethylene glycol (PEG) and superparamagnetic iron oxide nanoparticles has been developed and evaluated for the enhanced delivery of docetaxel (DTX) to breast cancer cells. The hydrothermally synthesized iron oxide nanoparticles (IONP) were encapsulated along with the DTX drug in a PLGA-PEG coating using a modified emulsion evaporation method. The structural, morphological and chemical characterization of the iron oxide nanoparticles was done by XRD, FE-SEM, TEM, DLS, and FTIR. The X-ray diffraction analysis showed good crystallinity of the nanoparticles. The magnetization versus field (M-H) curve revealed the superparamagnetic behavior of the synthesized IONPs at room temperature with a saturation magnetization of 71.9 emu·g⁻¹. The DTX loaded iron oxide nanoparticles (DIONP) showed …