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Diabet. Med. 27, 54–60 (2010)

Aims  Increased dietary fish‐oil consumption is associated with a reduced risk of coronary heart events and has pronounced effects on dyslipidaemia. However, the effects of fish‐oil supplement on vascular function and metabolic profile in patients with Type 2 diabetes mellitus (DM) are unclear.

Methods  In a double‐blind placebo‐controlled trial, we randomized 97 Type 2 DM patients without prior cardiovascular disease to fish‐oil (4 g/day, n = 49) or olive‐oil (with equivalent calories, as placebo, n = 48) supplements for 12 weeks. Assessment of vascular function with brachial artery flow‐mediated dilation (FMD) and circulating levels of endothelial progenitor cells (EPCs), and metabolic parameters, high‐sensitivity C‐reactive protein (hsCRP), oxidative stress markers and renal function were examined before and after the supplement.

Results  Despite a significant …