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Background Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear.

Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function.

Methods Fifty‐two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age‐ and sex‐matched controls. Baseline demographics and high‐sensitivity C‐reactive protein (hs‐CRP) level were recorded for each subject. Psoriatic disease activity was assessed using the Psoriasis Area and Severity Index (PASI). Arterial stiffness and endothelial function were assessed using brachial to ankle pulse wave velocity (baPWV) and digital hyperaemic response measured using the peripheral arterial tonometry (PAT) index.

Results Patients with …