作者
Venkat Raghavan Krishnaswamy, Dvir Mintz, Irit Sagi
发表日期
2017/11/1
来源
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
卷号
1864
期号
11
页码范围
2220-2227
出版商
Elsevier
简介
Cutaneous wound healing is a complex mechanism with multiple processes orchestrating harmoniously for structural and functional restoration of the damaged tissue. Chronic non-healing wounds plagued with infection create a major healthcare burden and is one of the most frustrating clinical problems. Chronic wounds are manifested by prolonged inflammation, defective re-epithelialization and haphazard remodeling. Matrix metalloproteinases (MMPs) are zinc dependent enzymes that play cardinal functions in wound healing. Understanding the pathological events mediated by MMPs during wound healing may pave way in identifying novel drug targets for chronic wounds. Here, we discuss the functions and skewed regulation of different MMPs during infection and chronic tissue repair. This review also points out the potential of MMPs and their inhibitors as therapeutic agents in treating chronic wounds during …
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VR Krishnaswamy, D Mintz, I Sagi - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2017