作者
J Joshua Smith, Paul Strombom, Oliver S Chow, Campbell S Roxburgh, Patricio Lynn, Anne Eaton, Maria Widmar, Karuna Ganesh, Rona Yaeger, Andrea Cercek, Martin R Weiser, Garrett M Nash, Jose G Guillem, Larissa KF Temple, Sree B Chalasani, James L Fuqua, Iva Petkovska, Abraham J Wu, Marsha Reyngold, Efsevia Vakiani, Jinru Shia, Neil H Segal, James D Smith, Christopher Crane, Marc J Gollub, Mithat Gonen, Leonard B Saltz, Julio Garcia-Aguilar, Philip B Paty
发表日期
2019/4/1
期刊
JAMA oncology
卷号
5
期号
4
页码范围
e185896-e185896
出版商
American Medical Association
简介
Importance
The watch-and-wait (WW) strategy aims to spare patients with rectal cancer unnecessary resection.
Objective
To analyze the outcomes of WW among patients with rectal cancer who had a clinical complete response to neoadjuvant therapy.
Design, Setting, and Participants
This retrospective case series analysis conducted at a comprehensive cancer center in New York included patients who received a diagnosis of rectal adenocarcinoma between January 1, 2006, and January 31, 2015. The median follow-up was 43 months. Data analyses were conducted from June 1, 2016, to October 1, 2018.
Exposures
Patients had a clinical complete response after completing neoadjuvant therapy and agreed to a WW strategy of active surveillance and possible salvage surgery (n = 113), or patients underwent total mesorectal excision and were found to have a pathologic complete response (pCR) at resection (n …
学术搜索中的文章
JJ Smith, P Strombom, OS Chow, CS Roxburgh… - JAMA oncology, 2019