作者
Mai Sasaki Aanensen Fraz, Annika Elisabet Michelsen, Natasha Moe, Trond Mogens Aaløkken, Magnhild Eide Macpherson, Ingvild Nordøy, Pål Aukrust, Eli Taraldsrud, Are Martin Holm, Thor Ueland, Silje Fjellgård Jørgensen, Børre Fevang
发表日期
2022/10
期刊
Journal of clinical immunology
卷号
42
期号
7
页码范围
1553-1563
出版商
Springer US
简介
Purpose
About 20–30% of patients with common variable immunodeficiency (CVID) develop granulomatous-lymphocytic interstitial lung disease (GLILD) as one of several non-infectious complications to their immunodeficiency. The purpose of this study was to identify biomarkers that could distinguish GLILD from other non-infectious complications in CVID.
Methods
We analyzed serum biomarkers related to inflammation, pulmonary epithelium injury, fibrogenesis, and extracellular matrix (ECM) remodeling, and compared three subgroups of CVID: GLILD patients (n = 16), patients with other non-infectious complications (n = 37), and patients with infections only (n = 20).
Results
We found that GLILD patients had higher levels of sCD25, sTIM-3, IFN-γ, and TNF, reflecting T cell activation and exhaustion, compared to both CVID patients with other inflammatory complications and CVID with infections only. GLILD …
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MSA Fraz, AE Michelsen, N Moe, TM Aaløkken… - Journal of clinical immunology, 2022