作者
Tonje Skarpengland, Magnhild E Macpherson, Johannes R Hov, Xiang Y Kong, Pavol Bohov, Bente Halvorsen, Børre Fevang, Rolf K Berge, Pål Aukrust, Silje F Jørgensen
发表日期
2022/1/1
期刊
Journal of Clinical Immunology
页码范围
1-12
出版商
Springer US
简介
Purpose
Fatty acid (FA) abnormalities are found in various inflammatory disorders and have been related to disturbed gut microbiota. Patients with common variable immunodeficiency (CVID) have inflammatory complications associated with altered gut microbial composition. We hypothesized that there is an altered FA profile in CVID patients, related to gut microbial dysbiosis.
Methods
Plasma FAs were measured in 39 CVID patients and 30 healthy controls. Gut microbial profile, a food frequency questionnaire, and the effect of the oral antibiotic rifaximin were investigated in CVID patients.
Results
The n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) (1.4 [1.0–1.8] vs. 1.9 [1.2–2.5], median (IQR), P < 0.05), and docosahexaenoic acid (DHA) (3.2 [2.4–3.9] vs. 3.5 [2.9–4.3], P < 0.05), all values expressed as …
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T Skarpengland, ME Macpherson, JR Hov, XY Kong… - Journal of Clinical Immunology, 2022