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Ulcerative colitis (UC) is a public health concern. The quest for drugs characterized by minimal side effects and optimal safety profiles for managing UC has emerged as a primary research topic. Recent evidence suggests the efficacy of Lactobacillus-derived exopolysaccharides containing mannose (MnEPSs) in alleviating UC. Lactobacillus could not synthesize MnEPSs in the glucose-only MRS medium, but with mannose added to the carbon source, MnEPSs were produced directionally, of which mannose accounts for 5.9%-7.8% of the total sugar content. Subsequently, MnEPS-6M3, MnEPS-Q5M22, MnEPS-D4L1, and MnEPS-CCFM 1393 were used to investigate the mechanism of UC relief. The results showed that compared with non-MnEPSs, MnEPSs had the better effect on reliving UC. Phenotypically, four MnEPSs alleviated weight loss, DAI score, crypt disappearance, inflammatory cell infiltration, and …