作者
Kohei Sato, James P Fisher, Thomas Seifert, Morten Overgaard, Niels H Secher, Shigehiko Ogoh
发表日期
2012/12/1
期刊
Experimental physiology
卷号
97
期号
12
页码范围
1272-1280
出版商
Blackwell Publishing Ltd
简介
It remains unclear whether orthostatic stress evokes regional differences in cerebral blood flow. The present study compared blood flow in the internal carotid (ICA) and vertebral arteries (VA) during orthostatic stress (60 deg head‐up tilt; HUT) in six healthy young men. The ICA and VA blood flow were measured using Doppler ultrasonography. Dynamic cerebral autoregulation was also determined during supine (Supine) and HUT conditions, from the rate of regulation (RoR) in cerebrovascular conductance of the ICA and VA during acute hypotension induced by the release of bilateral thigh‐cuffs. The HUT decreased ICA blood flow by −9.4 ± 1.7% (P < 0.01 versus Supine), leaving ICA conductance unchanged. In contrast, there was no significant difference in VA blood flow between Supine and HUT, and VA conductance increased (+12.9 ± 0.8%, P < 0.01). In addition, dynamic cerebral autoregulation in both the …
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