作者
Nassim Kamar, Florence Abravanel, Janick Selves, Cyril Garrouste, Laure Esposito, Laurence Lavayssière, Olivier Cointault, David Ribes, Isabelle Cardeau, Marie Béatrice Nogier, Jean Michel Mansuy, Fabrice Muscari, Jean Marie Peron, Jacques Izopet, Lionel Rostaing
发表日期
2010/2/15
期刊
Transplantation
卷号
89
期号
3
页码范围
353-360
出版商
LWW
简介
Background.
Hepatitis-E virus (HEV) infection can be responsible for chronic hepatitis in solid-organ transplant patients.
Methods.
We identified 33 cases of autochthonous acute HEV infection in solid-organ transplant patients.
Results.
Among 27 HEV-positive patients, who had a follow-up of more than 6 months, 16 (59.25%) evolved to chronic HEV infection, defined by persisting elevated liver-enzyme levels and positive serum HEV RNA 6 months after diagnosis. Serial liver biopsies showed progression in liver activity and liver fibrosis. Three patients developed liver cirrhosis. The proportion of patients receiving tacrolimus compared with cyclosporine A was significantly higher in patients who evolved to chronic disease. Immunosuppressive therapy was reduced in patients with chronic hepatitis; however, those who had a dramatic decrease in tacrolimus trough levels were more likely to clear the virus. Four chronic …
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N Kamar, F Abravanel, J Selves, C Garrouste… - Transplantation, 2010