作者
Sakari Jukarainen, Sini Heinonen, Joel T Rämö, Rita Rinnankoski-Tuikka, Elisabeth Rappou, Mark Tummers, Maheswary Muniandy, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Jaakko Kaprio, Aila Rissanen, Eija Pirinen, Kirsi H Pietiläinen
发表日期
2016/1/1
期刊
The Journal of Clinical Endocrinology
卷号
101
期号
1
页码范围
275-283
出版商
Endocrine Society
简介
Context
Sirtuins (SIRTs) regulate cellular metabolism and mitochondrial function according to the energy state of the cell reflected by NAD+ levels.
Objective
Our aim was to determine whether expressions of SIRTs and NAD+ biosynthesis genes are affected by acquired obesity and how possible alterations are connected with metabolic dysfunction while controlling for genetic and familial factors.
Design and Participants
We studied a cross-sectional sample of 40 healthy pairs of monozygotic twins, including 26 pairs who were discordant for body mass index (within-pair difference > 3 kg/m2), from the FinnTwin12 and FinnTwin16 cohorts.
Main Outcome Measures
Subcutaneous adipose tissue (SAT) transcriptomics was analyzed by using Affymetrix U133 Plus 2.0 chips, total SAT (poly-ADP) ribose polymerase (PARP) activity by an ELISA kit, body composition by dual-energy x-ray absorptiometry and magnetic …
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S Jukarainen, S Heinonen, JT Rämö… - The Journal of Clinical Endocrinology, 2016