作者
Frederic Michon, Mark Tummers, Marika Kyyrönen, Mikko J Frilander, Irma Thesleff
发表日期
2010/4/15
期刊
Developmental biology
卷号
340
期号
2
页码范围
355-368
出版商
Academic Press
简介
Teeth form as appendages of the ectoderm and their morphogenesis is regulated by tissue interactions mediated by networks of conserved signal pathways. Micro-RNA (miRNA) pathway has emerged as important regulator of various aspects of embryonic development, but its function in odontogenesis has not been elucidated. We show that the expression of RNAi pathway effectors is dynamic during tooth morphogenesis and differentiation of dental cells. Based on microarray profiling we selected 8 miRNAs expressed during morphogenesis and 7 miRNAs in the incisor cervical loop containing the stem cell niche. These miRNAs were mainly expressed in the dental epithelium. Conditional deletion of Dicer-1 in the epithelium (DcrK14−/−) resulted in rather mild but significant aberrations in tooth shape and enamel formation. The cusp patterns of the DcrK14−/− molar crowns resembled the patterns of both ancestral …
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F Michon, M Tummers, M Kyyrönen, MJ Frilander… - Developmental biology, 2010