作者
Orly Vardeny, KyungMann Kim, Jacob A Udell, Jacob Joseph, Akshay S Desai, Michael E Farkouh, Sheila M Hegde, Adrian F Hernandez, Allison McGeer, H Keipp Talbot, Inder Anand, Deepak L Bhatt, Christopher P Cannon, David DeMets, J Michael Gaziano, Shaun G Goodman, Kristin Nichol, Matthew C Tattersall, Jonathan L Temte, Janet Wittes, Clyde Yancy, Brian Claggett, Yi Chen, Lu Mao, Thomas C Havighurst, Lawton S Cooper, Scott D Solomon
发表日期
2021/1/5
期刊
Jama
卷号
325
期号
1
页码范围
39-49
出版商
American Medical Association
简介
Importance
Influenza is temporally associated with cardiopulmonary morbidity and mortality among those with cardiovascular disease who may mount a less vigorous immune response to vaccination. Higher influenza vaccine dose has been associated with reduced risk of influenza illness.
Objective
To evaluate whether high-dose trivalent influenza vaccine compared with standard-dose quadrivalent influenza vaccine would reduce all-cause death or cardiopulmonary hospitalization in high-risk patients with cardiovascular disease.
Design, Setting, and Participants
Pragmatic multicenter, double-blind, active comparator randomized clinical trial conducted in 5260 participants vaccinated for up to 3 influenza seasons in 157 sites in the US and Canada between September 21, 2016, and January 31, 2019. Patients with a recent acute myocardial infarction or heart failure hospitalization and at least 1 additional risk factor …
学术搜索中的文章
O Vardeny, KM Kim, JA Udell, J Joseph, AS Desai… - Jama, 2021
