作者
Martin H Steinberg, Franca Barton, Oswaldo Castro, Charles H Pegelow, Samir K Ballas, Abdullah Kutlar, Eugene Orringer, Rita Bellevue, Nancy Olivieri, James Eckman, Mala Varma, Gloria Ramirez, Brian Adler, Wally Smith, Timothy Carlos, Kenneth Ataga, Laura DeCastro, Carolyn Bigelow, Yogen Saunthararajah, Margaret Telfer, Elliott Vichinsky, Susan Claster, Susan Shurin, Kenneth Bridges, Myron Waclawiw, Duane Bonds, Michael Terrin
发表日期
2003/4/2
期刊
Jama
卷号
289
期号
13
页码范围
1645-1651
出版商
American Medical Association
简介
Context
Hydroxyurea increases levels of fetal hemoglobin (HbF) and decreases morbidity from vaso-occlusive complications in patients with sickle cell anemia (SCA). High HbF levels reduce morbidity and mortality.
Objective
To determine whether hydroxyurea attenuates mortality in patients with SCA.
Design
Long-term observational follow-up study of mortality in patients with SCA who originally participated in the randomized, double-blind, placebo-controlled Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH), conducted in 1992-1995, to determine if hydroxyurea reduces vaso-occlusive events. In the MSH Patients' Follow-up, conducted in 1996-2001, patients could continue, stop, or start hydroxyurea. Data were collected during the trial and in the follow-up period.
Setting
Inpatients and outpatients in 21 sickle cell referral centers in the United States and Canada.
Patients
Two-hundred ninety-nine adult …
引用总数
学术搜索中的文章
MH Steinberg, F Barton, O Castro, CH Pegelow… - Jama, 2003