作者
Catherine Orrell, David R Bangsberg, Motasim Badri, Robin Wood
发表日期
2003/6/13
期刊
Aids
卷号
17
期号
9
页码范围
1369-1375
出版商
LWW
简介
Objective:
to determine adherence of an indigent African HIV-infected cohort initiating antiretroviral therapy (ART); to identify predictors of incomplete adherence (< 95%) and virologic failure (> 400 HIV RNA copies/ml).
Design:
Prospective monitoring of adherence in a poor HIV-positive cohort, attending a public sector hospital and receiving ART through phase III studies.
Methods:
Adherence to ART was determined over 48 weeks by counting tabletreturns. Logistic regression models including age, WHO HIV stage, home language, socio-economic status, complexity and type of regimen were fitted to determine predictors of incomplete adherence and virologic failure at 48 weeks.
Results:
289 patients were recruited between January 1996 and May 2001. Median (mean) adherence of the cohort was 93.5%(87.2%). Three times daily dosing [risk ratio (RR), 3.07; 95% confidence interval (CI), 1.40–6.74], speaking English …
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C Orrell, DR Bangsberg, M Badri, R Wood - Aids, 2003