作者
Alicia K Smith, Andrew Ratanatharathorn, Adam X Maihofer, Robert K Naviaux, Allison E Aiello, Ananda B Amstadter, Allison E Ashley-Koch, Dewleen G Baker, Jean C Beckham, Marco P Boks, Evelyn Bromet, Michelle Dennis, Sandro Galea, Melanie E Garrett, Elbert Geuze, Guia Guffanti, Michael A Hauser, Seyma Katrinli, Varun Kilaru, Ronald C Kessler, Nathan A Kimbrel, Karestan C Koenen, Pei-Fen Kuan, Kefeng Li, Mark W Logue, Adriana Lori, Benjamin J Luft, Mark W Miller, Jane C Naviaux, Nicole R Nugent, Xuejun Qin, Kerry J Ressler, Victoria B Risbrough, Bart PF Rutten, Murray B Stein, Robert J Ursano, Eric Vermetten, Christiaan H Vinkers, Lin Wang, Nagy A Youssef, Monica Uddin, Caroline M Nievergelt
发表日期
2020/11/24
期刊
Nature communications
卷号
11
期号
1
页码范围
5965
出版商
Nature Publishing Group UK
简介
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls. Although AHRR methylation is known to associate with smoking, the AHRR association with PTSD is most pronounced in non-smokers, suggesting the result was independent of smoking status. Evaluation of metabolomics data reveals that AHRR methylation associated with kynurenine levels, which are lower among subjects with PTSD. This study supports epigenetic differences in those with …
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AK Smith, A Ratanatharathorn, AX Maihofer… - Nature communications, 2020