作者
Sang Joon Ahn, Ibra S Fancher, Jing‐Tan Bian, Chong Xu Zhang, Sarah Schwab, Robert Gaffin, Shane A Phillips, Irena Levitan
发表日期
2017/4/1
期刊
The Journal of Physiology
卷号
595
期号
7
页码范围
2339-2364
简介
Key points
- Endothelial inwardly rectifying K+ (Kir2.1) channels regulate flow‐induced vasodilatation via nitric oxide (NO) in mouse mesenteric resistance arteries.
- Deficiency of Kir2.1 channels results in elevated blood pressure and increased vascular resistance.
- Flow‐induced vasodilatation in human resistance arteries is also regulated by inwardly rectifying K+ channels.
- This study presents the first direct evidence that Kir channels play a critical role in physiological endothelial responses to flow.
Abstract
Inwardly rectifying K+ (Kir) channels are known to be sensitive to flow, but their role in flow‐induced endothelial responses is not known. The goal of this study is to establish the role of Kir channels in flow‐induced vasodilatation and to provide first insights into the mechanisms responsible for Kir signalling in this process. First, we establish that primary endothelial cells isolated from murine mesenteric arteries …
学术搜索中的文章
SJ Ahn, IS Fancher, JT Bian, CX Zhang, S Schwab… - The Journal of Physiology, 2017