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To the Editor: Chronic hypertension is associated with arterial endothelial dysfunction, the precursor to atherosclerosis (1); however, less is known about the effects of brief episodes of hypertension on endothelial function. Lamping and Dole (2) demonstrated that 5 min of moderate elevations in perfusion pressure reduces conduit coronary arterial endothelial function for up to 2.5 h. This endothelial dysfunction also extends to the human microcirculation (3). Cardiovascular benefits of exercise extend to both aerobic and resistance exercise and include improved endothelial function (4). However, weight lifting elevates systolic blood pressure (SBP) up to 400 mm Hg (5), possibly impairing endothelial function. We examined whether brief elevations in arterial pressure during weight lifting impair brachial arterial endothelial function assessed by flow-mediated vasodilation (FMD). Nine men and 5 women, age 28 2 …