作者
Benoît Marin, Farid Boumédiene, Giancarlo Logroscino, Philippe Couratier, Marie-Claude Babron, Anne Louise Leutenegger, Massimilano Copetti, Pierre-Marie Preux, Ettore Beghi
发表日期
2017/2/1
来源
International journal of epidemiology
卷号
46
期号
1
页码范围
57-74
出版商
Oxford University Press
简介
Background
To assess the worldwide variation of amyotrophic lateral sclerosis (ALS) incidence, we performed a systematic review and meta-analysis of population-based data published to date.
Methods
We reviewed Medline and Embase up to June 2015 and included all population-based studies of newly diagnosed ALS cases, using multiple sources for case ascertainment. ALS crude and standardized incidence (on age and sex using the US 2010 population) were calculated. Random effect meta-analysis and meta-regression were performed using the subcontinent as the main study level covariate. Sources of heterogeneity related to the characteristics of the study population and the study methodology were investigated.
Results
Among 3216 records, 44 studies were selected, covering 45 geographical areas in 11 sub-continents. A total of 13 146 ALS …
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