作者
Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret Mackinnon, Kathryn Maitland, Dominic P Kwiatkowski, Kirk A Rockett, Thomas N Williams, Amadou Abathina, Ismaela Abubakar, Eric Achidi, Tsiri Agbenyega, Mohammed Aiyegbo, Alex Akoto, Angela Allen, Stephen Allen, Lucas Amenga-Etego, Folakemi Amodu, Olukemi Amodu, Judith Anchang-Kimbi, Nana Ansah, Patrick Ansah, Daniel Ansong, Sampson Antwi, Thomas Anyorigiya, Tobias Apinjoh, Emmanuel Asafo-Agyei, Victor Asoala, Frank Atuguba, Sarah Auburn, Abdou Bah, Kariatou Bamba, Germana Bancone, David Barnwell, Abdoulaye Barry, Evasius Bauni, Richard Besingi, Kalifa Bojang, Edith Bougouma, Susan Bull, George Busby, Abdoulie Camara, Landing Camara, Susana Campino, Richard Carter, Dan Carucci, Climent Casals-Pascual, Ndey Ceesay, Pa Ceesay, Tran Chau, Ly Chuong, Taane Clark, Ramou Cole-Ceesay, David Conway, Katharine Cook, Olivia Cook, Victoria Cornelius, Patrick Corran, Simon Correa, Sharon Cox, Rachel Craik, Bakary Danso, Timothy Davis, Nicholas Day, Panos Deloukas, Awa Dembele, Jantina deVries, Rajika Dewasurendra, Mahamadou Diakite, Elizabeth Diarra, Yaya Dibba, Andrea Diss, Abdoulaye Djimdé, Amagana Dolo, Ogobara Doumbo, Alan Doyle, Chris Drakeley, Eleanor Drury, Patrick Duffy, Sarah Dunstan, Augustine Ebonyi, Ahmed Elhassan, Ibrahim Elhassan, Abier Elzein, Anthony Enimil, Pamela Esangbedo, Jennifer Evans, Julie Evans, Jeremy Farrar, Deepika Fernando, Kathryn Fitzpatrick, Janet Fullah, Jacob Garcia, Anita Ghansah, Michael Gottleib, Angie Green, Lee Hart, Meike Hennsman, Tran Hien, Nguyen Hieu, Eliza Hilton, Abraham Hodgson, Rolf Horstmann, Catherine Hughes, Ayman Hussein, Robert Hutton, Muntaser Ibrahim, Deus Ishengoma, Jula Jaiteh, Mariatou Jallow, Muminatou Jallow, Kebba Jammeh, Momodou Jasseh, Amie Jobarteh, Kimberly Johnson, Sarah Joseph, Dushyanth Jyothi, David Kachala, Dorcas Kamuya, Haddy Kanyi, Harin Karunajeewa, Nadira Karunaweera, Momodou Keita, Angeliki Kerasidou, Aja Khan, Katja Kivinen, Gilbert Kokwaro, Amadou Konate, Salimata Konate, Kwadwo Koram, Dominic Kwiatkowski, Moses Laman, Si Le, Ellen Leffler
发表日期
2018/8/1
期刊
The Lancet Haematology
卷号
5
期号
8
页码范围
e333-e345
出版商
Elsevier
简介
Background
Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.
Methods
We did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward of Kilifi County Hospital. We included as controls infants born in the local community between Aug 1, 2006, and Sept 30, 2010, who were part of a genetics study. We tested for associations between a range of candidate malaria-protective genes and risk for severe malaria and its specific phenotypes. We used a permutation approach to account for multiple comparisons between polymorphisms and …
学术搜索中的文章
CM Ndila, S Uyoga, AW Macharia, G Nyutu, N Peshu… - The Lancet Haematology, 2018
