作者
G Brandon Gunn, Pierre Blanchard, Adam S Garden, X Ronald Zhu, C David Fuller, Abdallah S Mohamed, William H Morrison, Jack Phan, Beth M Beadle, Heath D Skinner, Erich M Sturgis, Merrill S Kies, Kate A Hutcheson, David I Rosenthal, Radhe Mohan, Michael T Gillin, Steven J Frank
发表日期
2016/5/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
95
期号
1
页码范围
360-367
出版商
Elsevier
简介
Purpose
A single-institution prospective study was conducted to assess disease control and toxicity of proton therapy for patients with head and neck cancer.
Methods and Materials
Disease control, toxicity, functional outcomes, and patterns of failure for the initial cohort of patients with oropharyngeal squamous carcinoma (OPC) treated with intensity modulated proton therapy (IMPT) were prospectively collected in 2 registry studies at a single institution. Locoregional failures were analyzed by using deformable image registration.
Results
Fifty patients with OPC treated from March 3, 2011, to July 2014 formed the cohort. Eighty-four percent were male, 50% had never smoked, 98% had stage III/IV disease, 64% received concurrent therapy, and 35% received induction chemotherapy. Forty-four of 45 tumors (98%) tested for p16 were positive. All patients received IMPT (multifield optimization to n=46; single-field …
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GB Gunn, P Blanchard, AS Garden, XR Zhu, CD Fuller… - International Journal of Radiation Oncology* Biology …, 2016