作者
Kelly D McCall, Norikazu Harii, Christopher J Lewis, Ramiro Malgor, Won Bae Kim, Motoyasu Saji, Aimee D Kohn, Randall T Moon, Leonard D Kohn
发表日期
2007/9/1
期刊
Endocrinology
卷号
148
期号
9
页码范围
4226-4237
出版商
Oxford University Press
简介
High basal levels of TLR3 and Wnt5a RNA are present in papillary thyroid carcinoma (PTC) cell lines consistent with their overexpression and colocalization in PTC cells in vivo. This is not the case in thyrocytes from normal tissue and in follicular carcinoma (FC) or anaplastic carcinoma (AC) cells or tissues. The basally expressed TLR3 are functional in PTC cells as evidenced by the ability of double-strand RNA (polyinosine-polycytidylic acid) to significantly increase the activity of transfected NF-κB and IFN-β luciferase reporter genes and the levels of two end products of TLR3 signaling, IFN-β and CXCL10. Phenylmethimazole (C10), a drug that decreases TLR3 expression and signaling in FRTL-5 thyrocytes, decreases TLR3 levels and signaling in PTC cells in a concentration-dependent manner. C10 also decreased Wnt5a RNA levels coordinate with decreases in TLR3. E-cadherin RNA levels, whose …
引用总数
200820092010201120122013201420152016201720182019202020212022202320244676157132588425232