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A series of few triazole linked hydroxamic acid derivatives were designed virtually considering the basic pharmacophore of suberoyl anilide hydroxamic acid (SAHA). The least energy conformers of each molecule was generated and docked with human histone deacetylase (HDAC8) with PDB id 1T69 using Autodock 4.0. 1. Most of the molecules have shown significant binding interaction with the receptor. Among the test compounds, 1a and 1g have shown highest free energy of binding-7.04 kcal/mol and-7.23 kcal/mol respectively, which is comparable to that of the reference standard, SAHA.