查看文章

To determine whether nutritional support guided by repeated measurements of resting energy requirements improves the outcome of critically ill patients.

This was a prospective, randomized, single-center, pilot clinical trial conducted in an adult general intensive care (ICU) unit. The study population comprised mechanically ventilated patients (n = 130) expected to stay in ICU more than 3 days. Patients were randomized to receive enteral nutrition (EN) with an energy target determined either (1) by repeated indirect calorimetry measurements (study group, n = 56), or (2) according to 25 kcal/kg/day (control group, n = 56). EN was supplemented with parenteral nutrition when required.

The primary outcome was hospital mortality. Measured pre-study resting energy expenditure (REE) was similar in …