作者
Jean-Charles Preiser, Philippe Devos, Sergio Ruiz-Santana, Christian Mélot, Djillali Annane, Johan Groeneveld, Gaetano Iapichino, Xavier Leverve, Gérard Nitenberg, Pierre Singer, Jan Wernerman, Michael Joannidis, Adela Stecher, René Chioléro
发表日期
2009/10
期刊
Intensive care medicine
卷号
35
页码范围
1738-1748
出版商
Springer-Verlag
简介
Purpose
An optimal target for glucose control in ICU patients remains unclear. This prospective randomized controlled trial compared the effects on ICU mortality of intensive insulin therapy (IIT) with an intermediate glucose control.
Methods
Adult patients admitted to the 21 participating medico-surgical ICUs were randomized to group 1 (target BG 7.8–10.0 mmol/L) or to group 2 (target BG 4.4–6.1 mmol/L).
Results
While the required sample size was 1,750 per group, the trial was stopped early due to a high rate of unintended protocol violations. From 1,101 admissions, the outcomes of 542 patients assigned to group 1 and 536 of group 2 were analysed. The groups were well balanced. BG levels averaged in group 1 8.0 mmol/L (IQR 7.1–9.0) (median of all values) and 7.7 mmol/L (IQR 6.7–8.8) (median of morning BG …
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JC Preiser, P Devos, S Ruiz-Santana, C Mélot… - Intensive care medicine, 2009