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Ethanolic extract of bitter fraction of Stevia rebaudiana (Srbf) was extracted to investigate its antihyperglycemic and protective effects on renal structural changes in STZ-induced diabetes. Thirty-five male mice were divided into five groups randomly; the first group as non-diabetic control, the second group as untreated diabetic, the third group treated with glibenclamide 0.5 mg/kg, and the fourth and fifth groups treated with Srbf by 200 and 400 μg/kg bw through gavage, respectively, for 15 days. Diabetes was induced in the second to fifth groups by administration of 60 mg/kg bw of streptozotocin intraperitoneally. Serum glucose level was monitored every day. At the 16th day, the subjects were sacrificed and their left kidneys were removed. Tissue sections were stained by periodic acid Schiff and used for stereological analysis. The means were compared by one-way ANOVA and Tukey’s post hoc test at the …