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The ability of curcumin, a natural antioxidant from turmeric, to inhibit radiation-induced lipid peroxidation in rat liver microsomes was examined. Curcumin was incorporated into microsomes during ultracentrifugation. The antioxidant has significant time- and concentration-dependent inhibitory effect on lipid peroxidation induced by r-radiation. Inhibition of lipid peroxidation was also observed in microsomes samples previously saturated with N₂O. Curcumin also inhibited lipid peroxidation during the post-irradiation incubation.