查看文章

Synchronization of neural activity is fundamental for many functions of the brain. We demonstrate that spike-timing dependent plasticity (STDP) enhances synchronization (entrainment) in a hybrid circuit composed of a spike generator, a dynamic clamp emulating an excitatory plastic synapse, and a chemically isolated neuron from the Aplysia abdominal ganglion. Fixed-phase entrainment of the Aplysia neuron to the spike generator is possible for a much wider range of frequency ratios and is more precise and more robust with the plastic synapse than with a nonplastic synapse of comparable strength. Further analysis in a computational model of Hodgkin–Huxley-type neurons reveals the mechanism behind this significant enhancement in synchronization. The experimentally observed STDP plasticity curve appears to be designed to adjust synaptic strength to a value suitable for stable entrainment of the …