作者
Birgitte Berentsen, Bharath Halandur Nagaraja, Erica Pearson Teige, Gülen Arslan Lied, Astri J Lundervold, Katarina Lundervold, Elisabeth Kjelsvik Steinsvik, Eline Randulff Hillestad, Jørgen Valeur, Ingeborg Brønstad, Odd Helge Gilja, Berge Osnes, Jan Gunnar Hatlebakk, Judit Haász, Jennifer Labus, Arpana Gupta, Emeran A Mayer, Alfonso Benitez-Páez, Yolanda Sanz, Arvid Lundervold, Trygve Hausken
发表日期
2020/9/11
期刊
Medicine
卷号
99
期号
37
页码范围
e21950
出版商
LWW
简介
Introduction: Irritable bowel syndrome (IBS) is a common clinical label for medically unexplained gastrointestinal (GI) symptoms, recently described as a disturbance of the brain-gut-microbiota (BGM) axis. To gain a better understanding of the mechanisms underlying the poorly understood etiology of IBS, we have designed a multifaceted study that aim to stratify the complex interaction and dysfunction between the brain, the gut, and the microbiota in patients with IBS.
Methods: Deep phenotyping data from patients with IBS (n= 100) and healthy age-(between 18 and 65) and gender-matched controls (n= 40) will be collected between May 2019 and December 2021. Psychometric tests, questionnaires, human biological tissue/samples (blood, faeces, saliva, and GI biopsies from antrum, duodenum, and sigmoid colon), assessment of gastric accommodation and emptying using transabdominal ultrasound, vagal activity …
学术搜索中的文章
B Berentsen, BH Nagaraja, EP Teige, GA Lied… - Medicine, 2020