作者
Klaudyna Borewicz, Fangjie Gu, Edoardo Saccenti, Ilja CW Arts, John Penders, Carel Thijs, Sander S van Leeuwen, Cordula Lindner, Arjen Nauta, Ellen van Leusen, Henk A Schols, Hauke Smidt
发表日期
2019/7
期刊
Molecular Nutrition & Food Research
卷号
63
期号
13
页码范围
1801214
简介
Scope
Understanding the biological functions of human milk oligosaccharides (HMOs) in shaping gastrointestinal (GI) tract microbiota during infancy is of great interest. A link between HMOs in maternal milk and infant fecal microbiota composition is examined and the role of microbiota in degrading HMOs within the GI tract of healthy, breastfed, 1‐month‐old infants is investigated.
Methods and results
Maternal breast milk and infant feces are from the KOALA Birth Cohort. HMOs are quantified in milk and infant fecal samples using liquid chromatography‐mass spectrometry. Fecal microbiota composition is characterized using Illumina HiSeq 16S rRNA gene amplicon sequencing. The composition is associated with gender, delivery mode, and milk HMOs: Lacto‐N‐fucopentaose I and 2′‐fucosyllactose. Overall, Bifidobacterium, Bacteroides, Escherichia–Shigella, and Parabacteroides are predominating genera …
学术搜索中的文章
K Borewicz, F Gu, E Saccenti, ICW Arts, J Penders… - Molecular Nutrition & Food Research, 2019