作者
C Oakman, Leonardo Tenori, WM Claudino, S Cappadona, Stefano Nepi, A Battaglia, Patrizia Bernini, E Zafarana, Edoardo Saccenti, M Fornier, PG Morris, L Biganzoli, Claudio Luchinat, Ivano Bertini, A Di Leo
发表日期
2011/6/1
期刊
Annals of Oncology
卷号
22
期号
6
页码范围
1295-1301
出版商
Elsevier
简介
Background
Prognostic tools in early breast cancer are inadequate. The evolving field of metabolomics may allow more accurate identification of patients with residual micrometastases.
Patients and methods
Forty-four early breast cancer patients with pre- and postoperative serum samples had metabolomic assessment by nuclear magnetic resonance. Fifty-one metastatic patients served as control. Differential clustering was identified and used to calculate individual early patient ‘metabolomic risk’, calculated as inverse distance of each early patient from the metastatic cluster barycenter. Metabolomic risk was compared with Adjuvantionline 10-year mortality assessment.
Results
Innate serum metabolomic differences exist between early and metastatic patients. Preoperative patients were identified with 75% sensitivity, 69% specificity and 72% predictive accuracy. Comparison with Adjuvantionline revealed …
学术搜索中的文章
C Oakman, L Tenori, WM Claudino, S Cappadona… - Annals of Oncology, 2011