作者
Hoameng Ung, Christian Cazares, Ameya Nanivadekar, Lohith Kini, Joost Wagenaar, Danielle Becker, Abba Krieger, Timothy Lucas, Brian Litt, Kathryn A Davis
发表日期
2017/8/1
期刊
Brain
卷号
140
期号
8
页码范围
2157-2168
出版商
Oxford University Press
简介
See Kleen and Kirsch (doi:10.1093/awx178) for a scientific commentary on this article.
Cognitive deficits are common among epilepsy patients. In these patients, interictal epileptiform discharges, also termed spikes, are seen routinely on electroencephalography and believed to be associated with transient cognitive impairments. In this study, we investigated the effect of spikes on memory encoding and retrieval, taking into account the spatial distribution of spikes in relation to the seizure onset zone as well as anatomical regions of the brain. Sixty-seven patients with medication refractory epilepsy undergoing continuous intracranial electroencephalography monitoring engaged in a delayed free recall task to test short-term memory. In this task, subjects were asked to memorize and recall lists of common nouns. We quantified the effect of each spike on the probability of successful recall using a generalized …
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H Ung, C Cazares, A Nanivadekar, L Kini, J Wagenaar… - Brain, 2017