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The study objective was to conduct a systematic review and meta-analysis to assess the effectiveness of immersive virtual reality (VR)-supported interventions for patients with disorders or impairments. Web Science, MEDLINE, CINAHL Plus, and PsycINFO databases were searched from January 1990 to December 2020. We performed random-effects meta-analyses and calculated the standardized mean difference in the health outcomes before and after applying immersive VR-supported interventions. Forty-eight studies representing 52 experiments were meta-analyzed. Six different disorders or impairments were found to be examined in the experiments: anxiety disorders (n=40), psychotic disorders (n=3), poststroke motor impairment (n=3), mild cognitive impairment (MCI) (n=2), amblyopia (n=2), and unilateral vestibular hypofunction (UVH) (n=2). The use of VR interventions resulted in improvement in …