作者
Remus T Dame, Mariliis Tark‐Dame, Helmut Schiessel
发表日期
2011/12
期刊
Molecular microbiology
卷号
82
期号
6
页码范围
1311-1315
出版商
Blackwell Publishing Ltd
简介
Bacterial genomes are functionally organized. This organization is dynamic and globally changing throughout the cell cycle. Upon initiation of replication of the chromosome, the two origins segregate and move towards their new location taking along the newly replicated genome. Caulobacter crescentus employs a dedicated active partitioning (Par) system to move one copy of the parS centromere to the distal pole, while the other stays at the stalked pole. In this issue of Molecular Microbiology, Hong and McAdams describe studies on the speed of segregation of parS and regions up to 150 kb away. They show clear differences in segregation rates between parS and 50 kb flanking regions versus regions further away. To assess segregation rates the authors track fluorescent markers during movement using time‐lapse microscopy. The relation between genomic and physical distance of pairs of markers reflects …
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