作者
Jeffrey C‐Y Liu, Jörg Rottler, Lu Wang, Jenny Zhang, Chris D Pascoe, Bo Lan, Brandon A Norris, Ana M Herrera, Peter D Paré, Chun Y Seow
发表日期
2013/12/1
期刊
The Journal of physiology
卷号
591
期号
23
页码范围
5867-5878
出版商
Blackwell Publishing Ltd
简介
Key points
- • The length of myosin filaments was measured in three types of smooth muscle using serial electron microscopy.
- • The frequency distribution of myosin filament length for all three types of smooth muscle followed an exponential decay pattern.
- • The same frequency distribution pattern was observed in activated tracheal smooth muscle, although the average length was shorter compared with the filaments in relaxed smooth muscle.
- • Analysis suggests that the distribution pattern reflects a dynamic equilibrium between competing processes of linear polymerization and de‐polymerization of myosin dimers.
Abstract Myosin molecules from smooth muscle and non‐muscle cells are known to self‐assemble into side‐polar filaments in vitro. However, the in situ mechanism of filament assembly is not clear and the question of whether there is a unique length for myosin filaments in smooth muscle is …
学术搜索中的文章
JCY Liu, J Rottler, L Wang, J Zhang, CD Pascoe, B Lan… - The Journal of physiology, 2013