作者
Dustin Y Yoon, Christopher A Rippel, Andrew J Kobets, Christina M Morris, Jennifer E Lee, Phillip N Williams, Dana D Bridges, David J Vandenbergh, Yin Y Shugart, Harvey S Singer
发表日期
2007/7/5
期刊
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
卷号
144
期号
5
页码范围
605-610
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by involuntary motor and phonic tics. The pattern of inheritance and associated genetic abnormality has yet to be fully characterized. A dopaminergic abnormality in this disorder is supported by response to specific therapies, nuclear imaging, and postmortem studies. In this protocol, dopaminergic polymorphisms were examined for associations with TS and attention‐deficit hyperactivity disorder (ADHD). Polymorphisms investigated included the dopamine transporter (DAT1 DdeI and DAT1 VNTR), dopamine receptor (D4 Upstream Repeat and D4 VNTR), dopamine converting enzyme (dopamine β‐hydroxylase), and the acid phosphatase locus 1 (ACP1) gene. DNA was obtained from 266 TS individuals ± ADHD and 236 controls that were ethnicity‐matched. A significant association, using a genotype‐based association analysis, was …
引用总数
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DY Yoon, CA Rippel, AJ Kobets, CM Morris, JE Lee… - American Journal of Medical Genetics Part B …, 2007