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Diabetes mellitus is a metabolic disorder disease emanating from the inability of body’s response to high glucose levels in the blood. However, the side-effects from consuming synthetic drugs have reduced the effectiveness, thus, the potential of purple fleabane (Vernonia cinerea) leaf was investigated using microwave-assisted extraction (MAE) in this study. The influences of extraction factors such as irradiation time, microwave power level, feed/solvent, and ethanol concentration on the recovery yields of polyphenol and flavonoids were as well studied. Thirty experimental runs using a face-centered central composite design (FCCCD) with six centre points were employed and optimal yields were obtained by generating quadratic models based on response surface methodology. The obtained optimal MAE conditions were as follows: irradiation time, 2 min; microwave power level, 444 W; feed/solvent, 1:14 g/mL …